Traditional and non-traditional lipid parameters as risk factors for sudden sensorineural hearing loss.
Braz J Otorhinolaryngol
; 90(4): 101435, 2024.
Article
in En
| MEDLINE
| ID: mdl-38714080
ABSTRACT
OBJECTIVE:
The purpose was to explore the effects of traditional and non-traditional lipid parameters on Sudden Sensorineural Hearing Loss (SSNHL).METHODS:
The study included 452 patients diagnosed with SSNHL, among whom 206 patients had a level of hearing improvement ≥10â¯dB after one month of follow-up. A propensity score-matched (21) control group was used. Conditional and unconditional logistic regression were used to analyze the risk factors for SSNHL.RESULTS:
Patients with SSNHL had a higher risk of concomitant hypertension and elevated atherosclerogenic lipid levels, with apolipoprotein B and apolipoprotein E identified as independent risk factors for the onset of SSNHL. Additionally, the Lipid Comprehensive Index (LCI) was an independent risk factor for the degree of hearing loss. A positive linear correlation was revealed between triglyceride, non-high-density lipoprotein cholesterol, atherogenic index, Castelli risk index, atherogenic index of plasma, LCI and hearing loss. However, no linear relationship was observed between hearing gain and any lipid parameters. When Total Cholesterol (TC) was in the range of borderline high, the treatment effect was the best. However, the statistical significance disappeared upon adjusting for confounding factors.CONCLUSION:
Patients with SSNHL exhibited markedly dysregulated lipid metabolism. Elevated serum lipid levels may be a causative factor in auditory impairment and can influence the extent of hearing loss. Promptly improving cochlear microcirculation may benefit patients with borderline elevated TC.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hearing Loss, Sudden
/
Hearing Loss, Sensorineural
/
Lipids
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Braz J Otorhinolaryngol
Journal subject:
OTORRINOLARINGOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: