[Research progress on the role of imbalanced high and low molecular weight hyaluronic acid in respiratory system inflammation caused by atmospheric particulate matter].
Zhonghua Yu Fang Yi Xue Za Zhi
; 58(5): 608-614, 2024 May 06.
Article
in Zh
| MEDLINE
| ID: mdl-38715499
ABSTRACT
Atmospheric particulate matter has an association with respiratory system inflammation, and low molecular weight hyaluronic acid (LMW-HA) is a key biomarker of inflammatory cascade reaction. This review summarized the possible pathways and biomarkers of atmospheric particulate matter causing respiratory system inflammation through high molecular weight hyaluronic acid (HMW-HA)/LMW-HA imbalance, including the synthesis and decomposition of HA, the reduction of particulate matter and HMW-HA, the increase of LMW-HA, and the relationship between LMW-HA and respiratory system inflammation. Furthermore, inhibitors and therapeutic drugs targeting certain biomarkers were further listed. This review could shed light on the mechanism of respiratory system inflammation caused by atmospheric particulate matter and the weak points that need attention in subsequent research.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Particulate Matter
/
Hyaluronic Acid
/
Inflammation
Limits:
Humans
Language:
Zh
Journal:
Zhonghua Yu Fang Yi Xue Za Zhi
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: