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Formulation design and characterization of silymarin liposomes for enhanced antitumor activity.
Ke, Zhongcheng; Cheng, Xiaoling; Yang, Huimin; Niu, Yimin; Cheng, Xu; Ye, Ting; Sun, Guangying; Cheng, Ziyang; Sun, Yinyu.
Affiliation
  • Ke Z; College of Chemistry and Chemical Engineering, Huangshan University, Huangshan, Anhui, China/Research Center of Chinese Medicine Efficacy and Health Technology, Huangshan University, Huangshan, Anhui, China/College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
  • Cheng X; Health Supervision Institute, Tunxi District Health Bureau, Huangshan, Anhui, China.
  • Yang H; College of Chemistry and Chemical Engineering, Huangshan University, Huangshan, Anhui, China/Research Center of Chinese Medicine Efficacy and Health Technology, Huangshan University, Huangshan, Anhui, China.
  • Niu Y; College of Chemistry and Chemical Engineering, Huangshan University, Huangshan, Anhui, China/Research Center of Chinese Medicine Efficacy and Health Technology, Huangshan University, Huangshan, Anhui, China.
  • Cheng X; College of Chemistry and Chemical Engineering, Huangshan University, Huangshan, Anhui, China/Research Center of Chinese Medicine Efficacy and Health Technology, Huangshan University, Huangshan, Anhui, China.
  • Ye T; College of Chemistry and Chemical Engineering, Huangshan University, Huangshan, Anhui, China/Research Center of Chinese Medicine Efficacy and Health Technology, Huangshan University, Huangshan, Anhui, China.
  • Sun G; College of Chemistry and Chemical Engineering, Huangshan University, Huangshan, Anhui, China/ Research Center of Chinese Medicine Efficacy and Health Technology, Huangshan University, Huangshan, Anhui, China.
  • Cheng Z; College of Chemistry and Chemical Engineering, Huangshan University, Huangshan, Anhui, China/Research Center of Chinese Medicine Efficacy and Health Technology, Huangshan University, Huangshan, Anhui, China.
  • Sun Y; College of Chemistry and Chemical Engineering, Huangshan University, Huangshan, Anhui, China/Research Center of Chinese Medicine Efficacy and Health Technology, Huangshan University, Huangshan, Anhui, China.
Pak J Pharm Sci ; 37(1): 139-145, 2024 Jan.
Article in En | MEDLINE | ID: mdl-38741410
ABSTRACT
Liposomes, a nanoscale carrier, plays an important role in the delivery of drug, affects the in vivo efficacy of drugs. In this paper, silymarin(SM)-loaded liposomes was optimized using the response surface method (RSM), with entrapment efficiency (EE%) as an index. The formulation was optimized as follow lecithin (7.8mg/mL), SM/lecithin (1/26) and lecithin/cholesterol (10/1). The optimized SM liposomes had a high EE (96.58 ±3.06%), with a particle size of 290.3 ±10.5nm and a zeta potential of +22.98 ±1.73mV. In vitro release tests revealed that SM was released in a sustained-release manner, primarily via diffusion mechanism. In vitro cytotoxicity studies demonstrated that the prepared SM liposomes had stronger inhibitory effects than the model drug. Overall, these results indicate that this liposome system is suitable for intravenous delivery to enhance the antitumor effects of SM.
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Collection: 01-internacional Database: MEDLINE Main subject: Particle Size / Silymarin / Lecithins / Liposomes Limits: Humans Language: En Journal: Pak J Pharm Sci Journal subject: FARMACIA / FARMACOLOGIA / QUIMICA Year: 2024 Document type: Article Affiliation country: Country of publication:
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Add to My VHL
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Particle Size / Silymarin / Lecithins / Liposomes Limits: Humans Language: En Journal: Pak J Pharm Sci Journal subject: FARMACIA / FARMACOLOGIA / QUIMICA Year: 2024 Document type: Article Affiliation country: Country of publication: