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Fully Biodegradable Elastomer-Based Device for Oral Macromolecule Delivery.
McCabe, Reece; Eklund Thamdrup, Lasse Højlund; Ghavami, Mahdi; Boisen, Anja.
Affiliation
  • McCabe R; The Danish National Research Foundation and Villum Foundation's Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN), Department of Health Technology, Technical University of Denmark, 2800 Kgs Lyngby, Denmark.
  • Eklund Thamdrup LH; The Danish National Research Foundation and Villum Foundation's Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN), Department of Health Technology, Technical University of Denmark, 2800 Kgs Lyngby, Denmark.
  • Ghavami M; The Danish National Research Foundation and Villum Foundation's Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN), Department of Health Technology, Technical University of Denmark, 2800 Kgs Lyngby, Denmark.
  • Boisen A; The Danish National Research Foundation and Villum Foundation's Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN), Department of Health Technology, Technical University of Denmark, 2800 Kgs Lyngby, Denmark.
ACS Appl Bio Mater ; 7(6): 3777-3785, 2024 Jun 17.
Article in En | MEDLINE | ID: mdl-38754861
ABSTRACT
Oral devices, such as foil-type devices, show great potential for the delivery of poorly permeable macromolecules by enabling unidirectional release of the loaded pharmaceutical composition in close proximity to the epithelium in the small intestine or colon. However, one of the primary concerns associated with the use of foil-type devices so far has been the utilization of nonbiodegradable elastomers in the fabrication of the devices. Therefore, research into biodegradable substitute materials with similar characteristics enables drug delivery in a sustainable and environmentally friendly manner. In this study, a biodegradable elastomer, polyoctanediol citrate (POC), was synthesized via a one-pot reaction, with subsequent purification and microscale pattern replication via casting. The microstructure geometry was designed to enable fabrication of foil-type devices with the selected elastomer, which has a high intrinsic surface free energy. The final elastomer was demonstrated to have an elastic modulus ranging up to 2.2 ± 0.1 MPa, with strain at failure up to 110.1 ± 1.5%. Devices were loaded with acetaminophen and enterically coated, demonstrating 100% release at 2.5 h, following dissolution for 1 h in 0.1 M hydrochloric acid and 1.5 h in pH 6.8 phosphate-buffered saline. The elastomer demonstrated promising properties based on mechanical testing, surface free energy evaluation, and degradation studies.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Particle Size / Biocompatible Materials / Materials Testing / Elastomers Limits: Humans Language: En Journal: ACS Appl Bio Mater Year: 2024 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Particle Size / Biocompatible Materials / Materials Testing / Elastomers Limits: Humans Language: En Journal: ACS Appl Bio Mater Year: 2024 Document type: Article Affiliation country: