Mesenchymal stromal cells protect tissues from Th1 immune responses via IL-11 secretion.
FASEB J
; 38(10): e23683, 2024 May 31.
Article
in En
| MEDLINE
| ID: mdl-38758184
ABSTRACT
Mesenchymal stromal cells (MSCs) have been shown to modulate the function of various subsets of T cells such as naïve CD4+ T cells and IFNγ+CD4+ Th1 cells; however, mechanisms underlying this regulation have not been fully deciphered. Our in vitro culture assays demonstrate that MSCs suppress the activation and function of CD4+ T cells by secreting interleukin 11, and neutralization of IL11 abrogates MSC-mediated suppression of CD4+ T cell function. Moreover, delayed-type, exogenous supplementation of IL11 significantly suppressed IFNγ+ expression by Th1 cells. Th1 and CD8+ cells play central roles in T cell-mediated tissue damage. Using a murine model of hypersensitivity response to study T cell-mediated tissue damage, we show that silencing IL11 in MSCs significantly abates the capacity of MSCs to suppress the generation of IFNγ-secreting CD4+ and CD8+ cells, failing to prevent T cell-mediated tissue inflammation and tissue damage.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Interleukin-11
/
Th1 Cells
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Mesenchymal Stem Cells
Limits:
Animals
Language:
En
Journal:
FASEB J
/
FASEB j
/
FASEB journal
Journal subject:
BIOLOGIA
/
FISIOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: