Early infiltrating NKT lymphocytes attenuate bone regeneration through secretion of CXCL2.
Sci Adv
; 10(20): eadl6343, 2024 May 17.
Article
in En
| MEDLINE
| ID: mdl-38758783
ABSTRACT
Trauma rapidly mobilizes the immune response of surrounding tissues and activates regeneration program. Manipulating immune response to promote tissue regeneration shows a broad application prospect. However, the understanding of bone healing dynamics at cellular level remains limited. Here, we characterize the landscape of immune cells after alveolar bone injury and reveal a pivotal role of infiltrating natural killer T (NKT) cells. We observe a rapid increase in NKT cells after injury, which inhibit osteogenic differentiation of mesenchymal stem cells (MSCs) and impair alveolar bone healing. Cxcl2 is up-regulated in NKT cells after injury. Systemic administration of CXCL2-neutralizing antibody or genetic deletion of Cxcl2 improves the bone healing process. In addition, we fabricate a gelatin-based porous hydrogel to deliver NK1.1 depletion antibody, which successfully promotes alveolar bone healing. In summary, our study highlights the importance of NKT cells in the early stage of bone healing and provides a potential therapeutic strategy for accelerating bone regeneration.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteogenesis
/
Bone Regeneration
/
Chemokine CXCL2
/
Natural Killer T-Cells
Limits:
Animals
Language:
En
Journal:
Sci Adv
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: