The Functional Relationship Between RNA Splicing and the Chromatin Landscape.
J Mol Biol
; 436(16): 168614, 2024 Aug 15.
Article
in En
| MEDLINE
| ID: mdl-38762032
ABSTRACT
Chromatin is a highly regulated and dynamic structure that has been shown to play an essential role in transcriptional and co-transcriptional regulation. In the context of RNA splicing, early evidence suggested a loose connection between the chromatin landscape and splicing. More recently, it has been shown that splicing occurs in a co-transcriptional manner, meaning that the splicing process occurs in the context of chromatin. Experimental and computational evidence have also shown that chromatin dynamics can influence the splicing process and vice versa. However, much of this evidence provides mainly correlative relationships between chromatin and splicing with just a few concrete examples providing defined molecular mechanisms by which these two processes are functionally related. Nevertheless, it is clear that chromatin and RNA splicing are tightly interconnected to one another. In this review, we highlight the current state of knowledge of the relationship between chromatin and splicing.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromatin
/
RNA Splicing
Limits:
Animals
/
Humans
Language:
En
Journal:
J Mol Biol
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: