A genome-wide association study identifies a locus associated with knee extension strength in older Japanese individuals.
Commun Biol
; 7(1): 513, 2024 May 20.
Article
in En
| MEDLINE
| ID: mdl-38769351
ABSTRACT
Sarcopenia is a common skeletal muscle disease in older people. Lower limb muscle strength is a good predictive value for sarcopenia; however, little is known about its genetic components. Here, we conducted a genome-wide association study (GWAS) for knee extension strength in a total of 3452 Japanese aged 60 years or older from two independent cohorts. We identified a significant locus, rs10749438 which is an intronic variant in TACC2 (transforming acidic coiled-coil-containing 2) (P = 4.2 × 10-8). TACC2, encoding a cytoskeleton-related protein, is highly expressed in skeletal muscle, and is reported as a target of myotonic dystrophy 1-associated splicing alterations. These suggest that changes in TACC2 expression are associated with variations in muscle strength in older people. The association was consistently observed in young and middle-aged subjects. Our findings would shed light on genetic components of lower limb muscle strength and indicate TACC2 as a potential therapeutic target for sarcopenia.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Muscle Strength
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Genome-Wide Association Study
Limits:
Aged
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Female
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Humans
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Male
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Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Commun Biol
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: