Not too much, not too little-just the right amount: the story of YAP in the podocyte.
Kidney Int
; 105(6): 1157-1159, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38777398
ABSTRACT
Chen et al. identify dysregulation of the transcriptional activator Yes-associated protein in the podocytes of diabetic mouse and human kidneys. Podocyte Yes-associated protein deficiency led to downregulation of the key transcription factor Wilms' tumor 1, and worsened podocyte injury in a mouse model of diabetic kidney injury. Yes-associated protein may therefore play a critical role in diabetic podocyte injury via regulation of Wilms' tumor 1 expression.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transcription Factors
/
WT1 Proteins
/
Adaptor Proteins, Signal Transducing
/
Diabetic Nephropathies
/
Podocytes
/
YAP-Signaling Proteins
Limits:
Animals
/
Humans
Language:
En
Journal:
Kidney Int
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: