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The potential role of Tirzepatide as adjuvant therapy in countering colistin-induced nephro and neurotoxicity in rats via modulation of PI3K/p-Akt/GSK3-ß/NF-kB p65 hub, shielding against oxidative and endoplasmic reticulum stress, and activation of p-CREB/BDNF/TrkB cascade.
Hassan, Noha F; Ragab, Diaa; Ibrahim, Shaimaa G; Abd El-Galil, Mona M; Hassan Abd-El-Hamid, Asmaa; Hamed, Dalia M; Magdy William, Mira; Salem, Maha A.
Affiliation
  • Hassan NF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt. Electronic address: Noha.Fawzy@pharm.mti.edu.eg.
  • Ragab D; Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Sadat City, Menoufia, Egypt.
  • Ibrahim SG; Department of Pharmacology and Toxicology, Faculty of Pharmacy, October 6 University, Giza, Egypt.
  • Abd El-Galil MM; Department of Histology and Cell Biology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
  • Hassan Abd-El-Hamid A; Department of Histology and Cell Biology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
  • Hamed DM; Department of Microbiology and Immunology, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt.
  • Magdy William M; Department of Biochemistry, Faculty of Pharmacy, October 6 University, Giza, Egypt.
  • Salem MA; Department of Pharmacology and Toxicology, pharmacy program, Saint Petersburg University in Cairo, Cairo, Egypt.
Int Immunopharmacol ; 135: 112308, 2024 Jun 30.
Article in En | MEDLINE | ID: mdl-38788447
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Cyclic AMP Response Element-Binding Protein / Colistin / Oxidative Stress / Brain-Derived Neurotrophic Factor / Proto-Oncogene Proteins c-akt / Endoplasmic Reticulum Stress / Glycogen Synthase Kinase 3 beta / Kidney Limits: Animals Language: En Journal: Int Immunopharmacol Journal subject: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Year: 2024 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Cyclic AMP Response Element-Binding Protein / Colistin / Oxidative Stress / Brain-Derived Neurotrophic Factor / Proto-Oncogene Proteins c-akt / Endoplasmic Reticulum Stress / Glycogen Synthase Kinase 3 beta / Kidney Limits: Animals Language: En Journal: Int Immunopharmacol Journal subject: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Year: 2024 Document type: Article Country of publication: