The potential role of Tirzepatide as adjuvant therapy in countering colistin-induced nephro and neurotoxicity in rats via modulation of PI3K/p-Akt/GSK3-ß/NF-kB p65 hub, shielding against oxidative and endoplasmic reticulum stress, and activation of p-CREB/BDNF/TrkB cascade.
Int Immunopharmacol
; 135: 112308, 2024 Jun 30.
Article
in En
| MEDLINE
| ID: mdl-38788447
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Signal Transduction
/
Cyclic AMP Response Element-Binding Protein
/
Colistin
/
Oxidative Stress
/
Brain-Derived Neurotrophic Factor
/
Proto-Oncogene Proteins c-akt
/
Endoplasmic Reticulum Stress
/
Glycogen Synthase Kinase 3 beta
/
Kidney
Limits:
Animals
Language:
En
Journal:
Int Immunopharmacol
Journal subject:
ALERGIA E IMUNOLOGIA
/
FARMACOLOGIA
Year:
2024
Document type:
Article
Country of publication: