Biotransformation of chenodeoxycholic acid by human intestinal fungi and the agonistic effects on FXR.
Phytochemistry
; 224: 114162, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38797255
ABSTRACT
Bile acids play a vital role in modulating host metabolism, with chenodeoxycholic acid (CDCA) standing out as a primary bile acid that naturally activates farnesoid X receptor (FXR). In this study, we investigated the microbial transformations of CDCA by seven human intestinal fungal species. Our findings revealed that hydroxylation and dehydrogenation were the most prevalent metabolic pathways. Incubation of CDCA with Rhizopus microspores (PT2906) afforded eight undescribed compounds (6-13) alongside five known analogs (1-5) which were elucidated by HRESI-MS and NMR data. Notably, compounds 8, 12 and 13 exhibited an inhibitory effect on FXR in contrast to the FXR activation observed with CDCA in vitro assays. This study shone a light on the diverse transformations of CDCA by intestinal fungi, unveiling potential modulators of FXR activity with implications for host metabolism.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biotransformation
/
Chenodeoxycholic Acid
/
Receptors, Cytoplasmic and Nuclear
Limits:
Humans
Language:
En
Journal:
Phytochemistry
Year:
2024
Document type:
Article