Research Progress on CARM1 and its Relationship with Colorectal Cancer.
Cancer Invest
; 42(5): 435-442, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38813691
ABSTRACT
Coactivator-associated arginine methyltransferase 1 (CARM1) is significant as a key member of the PRMT family, crucial for regulating arginine methylation, and its association with colorectal cancer underscores its potential as a therapeutic target. Consequently, CARM1 inhibitors have emerged as potential therapeutic agents in cancer treatment and valuable chemical tools for cancer research. Despite steady progress in CARM1 inhibitor research, challenges persist in discovering effective, isoform-selective, cell-permeable, and in vivo-active CARM1 inhibitors for colorectal cancer. This review summarizes the research progress on CARM1 and its relationship with colorectal cancer, aiming to provide a theoretical basis for the radiotherapy of colorectal cancer.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protein-Arginine N-Methyltransferases
/
Colorectal Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Cancer Invest
/
Cancer invest
/
Cancer investigation
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: