Aging atlas reveals cell-type-specific effects of pro-longevity strategies.
Nat Aging
; 4(7): 998-1013, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38816550
ABSTRACT
Organismal aging involves functional declines in both somatic and reproductive tissues. Multiple strategies have been discovered to extend lifespan across species. However, how age-related molecular changes differ among various tissues and how those lifespan-extending strategies slow tissue aging in distinct manners remain unclear. Here we generated the transcriptomic Cell Atlas of Worm Aging (CAWA, http//mengwanglab.org/atlas ) of wild-type and long-lived strains. We discovered cell-specific, age-related molecular and functional signatures across all somatic and germ cell types. We developed transcriptomic aging clocks for different tissues and quantitatively determined how three different pro-longevity strategies slow tissue aging distinctively. Furthermore, through genome-wide profiling of alternative polyadenylation (APA) events in different tissues, we discovered cell-type-specific APA changes during aging and revealed how these changes are differentially affected by the pro-longevity strategies. Together, this study offers fundamental molecular insights into both somatic and reproductive aging and provides a valuable resource for in-depth understanding of the diversity of pro-longevity mechanisms.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aging
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Caenorhabditis elegans
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Transcriptome
/
Longevity
Limits:
Animals
Language:
En
Journal:
Nat Aging
Year:
2024
Document type:
Article
Affiliation country: