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Beyond memory impairment: the complex phenotypic landscape of Alzheimer's disease.
Argyriou, Stathis; Fullard, John F; Krivinko, Josh M; Lee, Donghoon; Wingo, Thomas S; Wingo, Aliza P; Sweet, Robert A; Roussos, Panos.
Affiliation
  • Argyriou S; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Genetics
  • Fullard JF; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Genetics
  • Krivinko JM; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
  • Lee D; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Genetics
  • Wingo TS; Goizueta Alzheimer's Disease Center, Emory University School of Medicine, Atlanta, GA, USA; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
  • Wingo AP; Department of Psychiatry, Emory University School of Medicine, Atlanta, GA, USA; Veterans Affairs Atlanta Health Care System, Decatur, GA, USA.
  • Sweet RA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Roussos P; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Genetics
Trends Mol Med ; 30(8): 713-722, 2024 Aug.
Article in En | MEDLINE | ID: mdl-38821772
ABSTRACT
Neuropsychiatric symptoms (NPSs) in Alzheimer's disease (AD) constitute multifaceted behavioral manifestations that reflect processes of emotional regulation, thinking, and social behavior. They are as prevalent in AD as cognitive impairment and develop independently during the progression of neurodegeneration. As studying NPSs in AD is clinically challenging, most AD research to date has focused on cognitive decline. In this opinion article we summarize emerging literature on the prevalence, time course, and the underlying genetic, molecular, and pathological mechanisms related to NPSs in AD. Overall, we propose that NPSs constitute a cluster of core symptoms in AD, and understanding their neurobiology can lead to a more holistic approach to AD research, paving the way for more accurate diagnostic tests and personalized treatments embracing the goals of precision medicine.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenotype / Alzheimer Disease Limits: Animals / Humans Language: En Journal: Trends Mol Med / Trends in molecular medicine / Trends mol. med Journal subject: BIOLOGIA MOLECULAR Year: 2024 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenotype / Alzheimer Disease Limits: Animals / Humans Language: En Journal: Trends Mol Med / Trends in molecular medicine / Trends mol. med Journal subject: BIOLOGIA MOLECULAR Year: 2024 Document type: Article Country of publication: