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Targeting mTOR and survivin concurrently potentiates radiation therapy in renal cell carcinoma by suppressing DNA damage repair and amplifying mitotic catastrophe.
Rachamala, Hari K; Madamsetty, Vijay S; Angom, Ramcharan S; Nakka, Naga M; Dutta, Shamit Kumar; Wang, Enfeng; Mukhopadhyay, Debabrata; Pal, Krishnendu.
Affiliation
  • Rachamala HK; Department of Biochemistry and Molecular Biology, Mayo Clinic Florida, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA.
  • Madamsetty VS; Department of Biochemistry and Molecular Biology, Mayo Clinic Florida, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA.
  • Angom RS; PolyARNA Therapeutics, One Kendal Square, Cambridge, MA, 01329, USA.
  • Nakka NM; Department of Biochemistry and Molecular Biology, Mayo Clinic Florida, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA.
  • Dutta SK; Department of Biochemistry and Molecular Biology, Mayo Clinic Florida, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA.
  • Wang E; Department of Biochemistry and Molecular Biology, Mayo Clinic Florida, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA.
  • Mukhopadhyay D; Department of Biochemistry and Molecular Biology, Mayo Clinic Florida, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA.
  • Pal K; Department of Biochemistry and Molecular Biology, Mayo Clinic Florida, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA. mukhopadhyay.debabrata@mayo.edu.
J Exp Clin Cancer Res ; 43(1): 159, 2024 Jun 06.
Article in En | MEDLINE | ID: mdl-38840237
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Renal Cell / Xenograft Model Antitumor Assays / DNA Repair / TOR Serine-Threonine Kinases / Survivin / Kidney Neoplasms Limits: Animals / Humans Language: En Journal: J Exp Clin Cancer Res Year: 2024 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Renal Cell / Xenograft Model Antitumor Assays / DNA Repair / TOR Serine-Threonine Kinases / Survivin / Kidney Neoplasms Limits: Animals / Humans Language: En Journal: J Exp Clin Cancer Res Year: 2024 Document type: Article Affiliation country: Country of publication: