The Role of High Dose Chemotherapy with Autologous Hematopoietic Cell Transplant in Relapsed/Refractory Ovarian Germ Cell Tumors: A Single Center Experience.
Clin Genitourin Cancer
; 22(4): 102106, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38852437
ABSTRACT
OBJECTIVE:
We aimed to investigate response rates, survival analyses and factors affecting survival in patients with relapsed or refractory ovarian germ cell tumours who had previously received multiple lines of treatment, including high-dose chemotherapy (HDC) and autologous stem cell transplantation (ASCT).METHODS:
This study was designed as a cross-sectional, retrospective study.RESULTS:
Twenty-one patients were included. After HDC + ASCT, complete response (CR) was observed in 11 patients (52.3%), partial response (PR) in 3 patients (14.3%), stable disease (SD) in 3 patients (14.3%) and progressive disease (PD) in 4 patients (19.1%). TRM was observed in 1 patient. Median follow-up was 51.7 months. Median PFS and OS after HDC + ASCT were calculated to be 6.0 months and 14.8 months, respectively.CONCLUSIONS:
Salvage HDC + ASCT is an effective option in the treatment of relapsed/refractory ovarian germ cell tumours, offering the potential for prolonged survival and cure.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovarian Neoplasms
/
Transplantation, Autologous
/
Antineoplastic Combined Chemotherapy Protocols
/
Salvage Therapy
/
Neoplasms, Germ Cell and Embryonal
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Hematopoietic Stem Cell Transplantation
/
Neoplasm Recurrence, Local
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Clin Genitourin Cancer
/
Clin. genitourin. cancer (Online)
/
Clinical genitourinary cancer (Online)
Journal subject:
NEOPLASIAS
/
UROLOGIA
Year:
2024
Document type:
Article
Country of publication: