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Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling.
Hobor, Sebastijan; Al Bakir, Maise; Hiley, Crispin T; Skrzypski, Marcin; Frankell, Alexander M; Bakker, Bjorn; Watkins, Thomas B K; Markovets, Aleksandra; Dry, Jonathan R; Brown, Andrew P; van der Aart, Jasper; van den Bos, Hilda; Spierings, Diana; Oukrif, Dahmane; Novelli, Marco; Chakrabarti, Turja; Rabinowitz, Adam H; Ait Hassou, Laila; Litière, Saskia; Kerr, D Lucas; Tan, Lisa; Kelly, Gavin; Moore, David A; Renshaw, Matthew J; Venkatesan, Subramanian; Hill, William; Huebner, Ariana; Martínez-Ruiz, Carlos; Black, James R M; Wu, Wei; Angelova, Mihaela; McGranahan, Nicholas; Downward, Julian; Chmielecki, Juliann; Barrett, Carl; Litchfield, Kevin; Chew, Su Kit; Blakely, Collin M; de Bruin, Elza C; Foijer, Floris; Vousden, Karen H; Bivona, Trever G; Hynds, Robert E; Kanu, Nnennaya; Zaccaria, Simone; Grönroos, Eva; Swanton, Charles.
Affiliation
  • Hobor S; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.
  • Al Bakir M; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.
  • Hiley CT; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.
  • Skrzypski M; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.
  • Frankell AM; Department of Medical Oncology, University College London Hospitals, 235 Euston Rd, Fitzrovia, London, NW1 2BU, UK.
  • Bakker B; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.
  • Watkins TBK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.
  • Markovets A; Department of Medical Oncology, University College London Hospitals, 235 Euston Rd, Fitzrovia, London, NW1 2BU, UK.
  • Dry JR; Department of Oncology and Radiotherapy, Medical University of Gdansk, ul. Mariana Smoluchowskiego 17, 80-214, Gdansk, Poland.
  • Brown AP; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.
  • van der Aart J; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.
  • van den Bos H; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.
  • Spierings D; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, Groningen, 9713, the Netherlands.
  • Oukrif D; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.
  • Novelli M; Oncology Data Science, Oncology R&D, AstraZeneca, Boston, MA, USA.
  • Chakrabarti T; Late Development, Oncology R&D, AstraZeneca, Boston, MA, USA.
  • Rabinowitz AH; Late Development, Oncology R&D, AstraZeneca, Boston, MA, USA.
  • Ait Hassou L; Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK.
  • Litière S; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, Groningen, 9713, the Netherlands.
  • Kerr DL; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, Groningen, 9713, the Netherlands.
  • Tan L; Research Department of Pathology, University College London Medical School, University Street, London, WC1E 6JJ, UK.
  • Kelly G; Research Department of Pathology, University College London Medical School, University Street, London, WC1E 6JJ, UK.
  • Moore DA; Department of Medicine, University of California, San Francisco, CA, 94158, USA.
  • Renshaw MJ; Furlong Laboratory, EMBL Meyerhofstraße 1, 69117, Heidelberg, Germany.
  • Venkatesan S; European Organization for Research and Treatment of Cancer, Brussels, Belgium.
  • Hill W; Bioinformatics & Biostatistics; Francis Crick Institute, London, UK.
  • Huebner A; Department of Medicine, University of California, San Francisco, CA, 94158, USA.
  • Martínez-Ruiz C; Department of Medicine, University of California, San Francisco, CA, 94158, USA.
  • Black JRM; Bioinformatics & Biostatistics; Francis Crick Institute, London, UK.
  • Wu W; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.
  • Angelova M; Department of Cellular Pathology, University College London Hospitals, London, UK.
  • McGranahan N; Advanced Light Microscopy, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.
  • Downward J; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.
  • Chmielecki J; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.
  • Barrett C; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.
  • Litchfield K; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.
  • Chew SK; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
  • Blakely CM; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.
  • de Bruin EC; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
  • Foijer F; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.
  • Vousden KH; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
  • Bivona TG; Department of Medicine, University of California, San Francisco, CA, 94158, USA.
  • Hynds RE; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.
  • Kanu N; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
  • Zaccaria S; Oncogene Biology Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.
  • Grönroos E; Late Development, Oncology R&D, AstraZeneca, Boston, MA, USA.
  • Swanton C; Late Development, Oncology R&D, AstraZeneca, Boston, MA, USA.
Nat Commun ; 15(1): 4871, 2024 Jun 13.
Article in En | MEDLINE | ID: mdl-38871738
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Suppressor Protein p53 / Chromosomal Instability / ErbB Receptors / Lung Neoplasms / Mutation Limits: Animals / Female / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2024 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Suppressor Protein p53 / Chromosomal Instability / ErbB Receptors / Lung Neoplasms / Mutation Limits: Animals / Female / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2024 Document type: Article Affiliation country: Country of publication: