Patterns of cognitive domain abnormalities enhance discrimination of dementia risk prediction: The ARIC study.
Alzheimers Dement
; 20(7): 4559-4571, 2024 07.
Article
in En
| MEDLINE
| ID: mdl-38877664
ABSTRACT
INTRODUCTION:
The contribution of neuropsychological assessments to risk assessment for incident dementia is underappreciated.METHODS:
We analyzed neuropsychological testing results in dementia-free participants in the Atherosclerosis Risk in Communities (ARIC) study. We examined associations of index domain-specific neuropsychological test performance with incident dementia using cumulative incidence curves and Cox proportional hazards models.RESULTS:
Among 5296 initially dementia-free participants (mean [standard deviation] age of 75.8 [5.1] years; 60.1% women, 22.2% Black) over a median follow-up of 7.9 years, the covariate-adjusted hazard ratio varied substantially depending on the pattern of domain-specific performance and age, in an orderly manner from single domain language abnormalities (lowest risk) to single domain executive or memory abnormalities, to multidomain abnormalities including memory (highest risk).DISCUSSION:
By identifying normatively defined cognitive abnormalities by domains based on neuropsychological test performance, there is a conceptually orderly and age-sensitive spectrum of risk for incident dementia that provides valuable information about the likelihood of progression. HIGHLIGHTS Domain-specific cognitive profiles carry enhanced prognostic value compared to mild cognitive impairment. Single-domain non-amnestic cognitive abnormalities have the most favorable prognosis. Multidomain amnestic abnormalities have the greatest risk for incident dementia. Patterns of domain-specific risks are similar by sex and race.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dementia
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Neuropsychological Tests
Limits:
Aged
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Aged80
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Female
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Humans
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Male
Language:
En
Journal:
Alzheimer's & dementia
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Alzheimers Dement
/
Alzheimers dememt
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: