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Subcutaneous edema as a potential cause of catheter failure in older inpatients receiving peripheral parenteral nutrition.
Kitada, Motoko; Yamamura, Shigeo; Hori, Etsuro.
Affiliation
  • Kitada M; Faculty of Nursing, Department of Nursing, Josai International University, Chiba, Japan.
  • Yamamura S; Faculty of Pharmaceutical Sciences, Department of Medical Pharmacy, Josai International University, Chiba, Japan.
  • Hori E; Behavioral Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Drug Discov Ther ; 18(3): 160-166, 2024 Jul 09.
Article in En | MEDLINE | ID: mdl-38880602
ABSTRACT
Malnutrition is a common problem among hospitalized older patients. Peripheral parenteral nutrition (PN) can improve patient outcomes but can also lead to complications that affect future treatment. Older inpatients, in particular, are expected to be prone to these catheter-related complications. However, the impact of peripheral PN on older inpatients has been rarely investigated. In the current study, the impact of PN on short peripheral catheters (SPCs) was evaluated by comparing signs and symptoms at the time of catheter removal between 22 patients with PN and 27 without. In addition to external clinical assessment, sonographic investigations of the SPC site were performed. The prevalence of external signs and symptoms of complications was similar between the patients (all P > 0.05). However, subcutaneous edema was found by ultrasound in > 80% of patients with PN, compared with 55.6% of those without PN (P = 0.051). Unlike cases without PN, all patients with PN who presented with external signs and symptoms developed subcutaneous edema (P = 0.022). Multivariate analysis demonstrated that administration of PN was independently associated with subcutaneous edema (adjusted odds ratio = 6.88, 95% confidence interval = 1.083-75.486, P = 0.040). For several decades, phlebitis has been the primary focus of complications related to peripheral PN in clinical settings. However, our results imply that peripheral PN causes subcutaneous edema, which can lead to catheter failure in older inpatients. This study contributes to understanding the etiology of catheter failure during peripheral PN in this population.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parenteral Nutrition / Edema Limits: Aged / Aged80 / Female / Humans / Male Language: En Journal: Drug Discov Ther Year: 2024 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parenteral Nutrition / Edema Limits: Aged / Aged80 / Female / Humans / Male Language: En Journal: Drug Discov Ther Year: 2024 Document type: Article Affiliation country: Country of publication: