Hemophagocytic Lymphohistiocytosis: A Rare Complication of Acute Hepatitis E Infection.
J Assoc Physicians India
; 72(4): 91-93, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38881088
ABSTRACT
Hemophagocytic lymphohistiocytosis (HLH) is an aggressive hematological disorder caused by uncontrolled activation of cytotoxic T-cells (CTL), natural killer (NK) cells, and macrophages leading to hyperinflammation and cytokine storm. The clinical course is characterized by high-grade fever, cytopenia, and multiorgan dysfunction. HLH is classified as either primary/familial or secondary, the latter being most often triggered by infections, malignancies, and autoimmune disorders. Viral infections are commonly known to cause HLH with Epstein-Barr virus (EBV), cytomegalovirus (CMV), influenza virus, adenovirus, and parvovirus being most often implicated. Hepatitis E virus (HEV) has infrequently been reported to cause HLH with less than five cases being reported in the literature. We report a case of a young man who presented with hepatitis E-associated HLH.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hepatitis E
/
Lymphohistiocytosis, Hemophagocytic
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
J Assoc Physicians India
Year:
2024
Document type:
Article