Development of the Cardiac Conduction System.
Adv Exp Med Biol
; 1441: 185-200, 2024.
Article
in En
| MEDLINE
| ID: mdl-38884712
ABSTRACT
The electrical impulses that coordinate the sequential, rhythmic contractions of the atria and ventricles are initiated and tightly regulated by the specialized tissues of the cardiac conduction system. In the mature heart, these impulses are generated by the pacemaker cardiomyocytes of the sinoatrial node, propagated through the atria to the atrioventricular node where they are delayed and then rapidly propagated to the atrioventricular bundle, right and left bundle branches, and finally, the peripheral ventricular conduction system. Each of these specialized components arise by complex patterning events during embryonic development. This chapter addresses the origins and transcriptional networks and signaling pathways that drive the development and maintain the function of the cardiac conduction system.
Key words
Atrioventricular bundle; Atrioventricular canal; Atrioventricular junction; Atrioventricular node; Bundle branches; Bundle of His; Cardiac conduction system; Conduction system; Pacemaker; Purkinje Fiber; Sinoatrial node; Sinus venosus; Ventricular conduction system; peripheral ventricular conduction system
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Heart Conduction System
Limits:
Animals
/
Humans
Language:
En
Journal:
Adv Exp Med Biol
Year:
2024
Document type:
Article
Affiliation country: