Posttranscriptional Regulation by Proteins and Noncoding RNAs.
Adv Exp Med Biol
; 1441: 313-339, 2024.
Article
in En
| MEDLINE
| ID: mdl-38884719
ABSTRACT
Posttranscriptional regulation comprises those mechanisms occurring after the initial copy of the DNA sequence is transcribed into an intermediate RNA molecule (i.e., messenger RNA) until such a molecule is used as a template to generate a protein. A subset of these posttranscriptional regulatory mechanisms essentially are destined to process the immature mRNA toward its mature form, conferring the adequate mRNA stability, providing the means for pertinent introns excision, and controlling mRNA turnover rate and quality control check. An additional layer of complexity is added in certain cases, since discrete nucleotide modifications in the mature RNA molecule are added by RNA editing, a process that provides large mature mRNA diversity. Moreover, a number of posttranscriptional regulatory mechanisms occur in a cell- and tissue-specific manner, such as alternative splicing and noncoding RNA-mediated regulation. In this chapter, we will briefly summarize current state-of-the-art knowledge of general posttranscriptional mechanisms, while major emphases will be devoted to those tissue-specific posttranscriptional modifications that impact on cardiac development and congenital heart disease.
Key words
5'end capping; ADAR; Alternative splicing; Cap-binding protein; GATA4; Immature mRNA; Mature RNA; Messenger RNA; NMD; Noncoding RNA; Nonsense-mediated decay; PITX2; Poly-A site; Polyadenylation; Posttranscriptional regulation; Pre-mRNA splicing; Premature translation termination codons; RNA editing; RNA guanylyltransferase and 5' triphosphatase; RNA maturation; RNA methyltransferase; RNA-binding proteins; Ribonucleoprotein; Ribosomal RNAs; S. cerevisiae; S. pombe; SCN5A; Small nuclear RNAs; Small nucleolar RNAs; Spliceosome; Splicing; Transfer RNAs; Translation; ZIC3; mRNA; mRNA capping; miRNA; microRNA; rRNAs; snRNAs; snoRNAs; tRNAs
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
RNA Processing, Post-Transcriptional
/
RNA, Untranslated
Limits:
Animals
/
Humans
Language:
En
Journal:
Adv Exp Med Biol
Year:
2024
Document type:
Article
Affiliation country: