Molecular Pathways and Animal Models of Arrhythmias.
Adv Exp Med Biol
; 1441: 1057-1090, 2024.
Article
in En
| MEDLINE
| ID: mdl-38884769
ABSTRACT
Arrhythmias account for over 300,000 annual deaths in the United States, and approximately half of all deaths are associated with heart disease. Mechanisms underlying arrhythmia risk are complex; however, work in humans and animal models over the past 25 years has identified a host of molecular pathways linked with both arrhythmia substrates and triggers. This chapter will focus on select arrhythmia pathways solved by linking human clinical and genetic data with animal models.
Key words
ACM; ANK2; Action potential; Ankyrin-B; Arrhythmogenic Cardiomyopathy; Brugada syndrome; CPVT; Calcium; Catecholaminergic polymorphic ventricular tachycardia; Channelopathies; ERS; Early repolarization syndrome; FKBP12.6; HERG; KCNE2; KCNJ2; KCNJ8; KCNQ1; LQTS; Long QT syndrome; RYR2; Reentry arrhythmias; Repolarization; Ryanodine receptor; SCN5A; SQTS; Short QT syndrome; Ventricular arrhythmias; atrial arrhythmias
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arrhythmias, Cardiac
/
Disease Models, Animal
Limits:
Animals
/
Humans
Language:
En
Journal:
Adv Exp Med Biol
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: