Design, optimization and characterization of atorvastatin loaded chitosan-based polyelectrolyte complex nanoparticles based transdermal patch.
Int J Biol Macromol
; 274(Pt 1): 133219, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38897514
ABSTRACT
AIM:
Atorvastatin (ATO) loaded chitosan-based polyelectrolyte complex nanoparticles (PECN) incorporated transdermal patch was developed to enhance its skin permeability and bioavailability.METHODOLOGY:
The ATO loaded PECN were prepared by ionic gelation method and optimized by Box-Behnken design. The optimized batches were evaluated for physicochemical characteristics, in vitro, ex vivo, cell line and stability studies. The optimized ATO-PECN were incorporated into transdermal patches by solvent evaporation method and evaluated for their physicochemical properties, ex vivo skin permeation, in vivo pharmacokinetics and stability study.RESULTS:
The optimized batch of ATO-PECN had average size of 219.2 ± 5.98 nm with 82.68 ± 2.63 % entrapment and 25.41 ± 3.29 mV zeta potential. ATO-PECN showed sustained drug release and higher skin permeation. The cell line study showed that ATO-PECN increased the cell permeability of ATO as compared to ATO suspension. ATO-PECN loaded transdermal patch showed higher skin permeation. The in vivo pharmacokinetic study revealed that the ATO-PECN transdermal patch showed significant (p < 0.05) increase in pharmacokinetic parameters as compared to marketed oral tablet, confirming enhancement in bioavailability of ATO.CONCLUSIONS:
The results of the present work concluded that the ATO-PECN loaded transdermal patch is a promising novel drug delivery system for poorly bioavailable drugs.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chitosan
/
Nanoparticles
/
Transdermal Patch
/
Atorvastatin
/
Polyelectrolytes
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Int J Biol Macromol
Year:
2024
Document type:
Article
Affiliation country: