Association of T-cell subtypes with macrophage-specific arterial infiltration in PWH.
AIDS
; 2024 Jun 21.
Article
in En
| MEDLINE
| ID: mdl-38905489
ABSTRACT
People with human immunodeficiency virus (HIV, PWH) face an increased risk of cardiovascular disease (CVD) compared to the general population. We previously demonstrated that people with (versus without) HIV have higher macrophage-specific arterial infiltration in relation to systemic monocyte activation. We now show that select T lymphocyte subpopulations (naïve CD4+, effector memory CD4+, and central memory CD8+) are differentially associated with macrophage-specific arterial infiltration among participants with versus without HIV, with evidence of interaction by HIV status. Our results suggest that among PWH, circulating T lymphocytes associate with macrophage-specific arterial infiltration, of relevance to atherogenesis and CVD risk. CLINICAL TRIALS REGISTRATION NCT02542371.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
AIDS
/
AIDS (Lond.)
/
AIDS (London, England)
Journal subject:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Year:
2024
Document type:
Article
Affiliation country:
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