Total Synthesis of (+)-Silybin A.
Chem Pharm Bull (Tokyo)
; 72(6): 570-573, 2024.
Article
in En
| MEDLINE
| ID: mdl-38910121
ABSTRACT
We report the first total synthesis of silybin A (1). Key synthetic steps include the construction of the 1,4-benzodioxane neolignan skeleton, a modified Julia-Kocienski olefination reaction between m-nitrophenyltetrazole sulfone (m-NPT sulfone) 10 and aldehyde 21, the formation of the flavanol lignan skeleton 28 via a quinomethide intermediate under acidic conditions, and stepwise oxidation of the benzylic position of flavanol 29.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Silybin
Language:
En
Journal:
Chem Pharm Bull (Tokyo)
/
Chem. pharm. bull
/
Chemical & pharmaceutical bulletin
Year:
2024
Document type:
Article
Country of publication: