Ischemic Post-Conditioning in a Rat Model of Asphyxial Cardiac Arrest.
Cells
; 13(12)2024 Jun 17.
Article
in En
| MEDLINE
| ID: mdl-38920675
ABSTRACT
BACKGROUND:
Ischemic post-conditioning (IPoC) has been shown to improve outcomes in limited pre-clinical models. As down-time is often unknown, this technique needs to be investigated over a range of scenarios. As this tool limits reperfusion injury, there may be limited benefit or even harm after short arrest and limited ischemia-reperfusion injury.METHODS:
Eighteen male Wistar rats underwent 7 min of asphyxial arrest. Animals randomized to IPoC received a 20 s pause followed by 20 s of compressions, repeated four times, initiated 40 s into cardiopulmonary resuscitation. If return of spontaneous circulation (ROSC) was achieved, epinephrine was titrated to mean arterial pressure (MAP) of 70 mmHg. Data were analyzed using t-test or Mann-Whitney test. Significance set at p ≤ 0.05.RESULTS:
The rate of ROSC was equivalent in both groups, 88%. There was no statistically significant difference in time to ROSC, epinephrine required post ROSC, carotid flow, or peak lactate at any timepoint. There was a significantly elevated MAP with IPoC, 90.7 mmHg (SD 13.9), as compared to standard CPR, 76.7 mmHg (8.5), 2 h after ROSC, p = 0.03.CONCLUSIONS:
IPoC demonstrated no harm in a model of short arrest using a new arrest etiology for CPR based IPoC intervention in a rat model.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Asphyxia
/
Rats, Wistar
/
Disease Models, Animal
/
Ischemic Postconditioning
/
Heart Arrest
Limits:
Animals
Language:
En
Journal:
Cells
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: