Development of iron-based single atom materials for general and efficient synthesis of amines.
Angew Chem Int Ed Engl
; : e202407859, 2024 Jun 24.
Article
in En
| MEDLINE
| ID: mdl-38923207
ABSTRACT
Heterogeneous catalysts with highly active and at the same time stable isolated metal sites constitute a key factor for the advancement of sustainable and cost-effective chemical synthesis. In particular, the development of more practical, and durable iron-based materials is of central interest for organic synthesis, especially for the preparation of chemical products related to life science applications. Here, we report the preparation of Fe-single atom catalysts (Fe-SACs) entrapped in N-doped mesoporous carbon support with unprecedented potential in the preparation of different kinds of amines. The synthetic protocol of Fe-SACs is based on primary pyrolysis of Fe-nitrogen complexes on SiO2 and subsequent removal of silica resulting in the formation of unique mesoporous N-doped carbon support with the pore size controlled by the size of the original silica nanoparticles. The resulting stable and reusable Fe-SACs allow for the reductive amination of a broad range of aldehydes and ketones with ammonia and amines to produce diverse primary, secondary, and tertiary amines including N-methylated products as well as drugs, agrochemicals, and other biomolecules (amino acid esters and amides) utilizing green hydrogen.
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Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Angew Chem Int Ed Engl
Year:
2024
Document type:
Article
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