Prevalence, Predictors, and Outcomes of Pulmonary Hypertension in Patients with Lupus Nephritis.
Medicina (Kaunas)
; 60(6)2024 Jun 17.
Article
in En
| MEDLINE
| ID: mdl-38929605
ABSTRACT
Background and Objectives:
This study aimed to assess the prevalence, predictors, and outcomes of pulmonary hypertension (PH) in patients with lupus nephritis (LN). Materials andMethods:
Baseline characteristics and clinical outcomes of 387 patients with LN were retrospectively collected from 2007 to 2017. PH was defined as pulmonary artery systolic pressure ≥40 mmHg assessed by resting transthoracic echocardiography. The primary endpoint was all-cause mortality. The secondary endpoint was renal events, defined as the doubling of baseline serum creatinine or end-stage renal disease. Associations between PH and outcomes were analyzed by Cox regression models.Results:
A total of 15.3% (59/387) of patients with LN were diagnosed with PH, and the prevalence of PH was higher for patients with an estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m2 compared to those with an eGFR ≥ 30 mL/min/1.73 m2 (31.5% vs. 12.6%). Higher mean arterial pressure, lower hemoglobin, and lower triglyceride levels were associated with greater odds of having PH. After adjusting for relevant confounding variables, PH was independently associated with a higher risk for death (HR 2.01; 95% CI 1.01-4.00; p = 0.047) and renal events (HR 2.07; 95% CI 1.04-4.12; p = 0.039).Conclusions:
PH is an independent risk factor for all-cause mortality and adverse renal outcomes in patients with LN.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lupus Nephritis
/
Hypertension, Pulmonary
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Medicina (Kaunas)
Journal subject:
MEDICINA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication:
CH
/
SUIZA
/
SUÍÇA
/
SWITZERLAND