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Evaluating predictions of the patterning cascade model of crown morphogenesis in the human lower mixed and permanent dentition.
Kenessey, Dori E; Stojanowski, Christopher M; Paul, Kathleen S.
Affiliation
  • Kenessey DE; Department of Anthropology, U niversity of Nevada, Reno, Nevada, United States of America.
  • Stojanowski CM; Center for Bioarchaeological Research, School of Human Evolution and Social Change, Arizona State University, Tempe, Arizona, United States of America.
  • Paul KS; Department of Anthropology, University of Arkansas, Fayetteville, Arkansas, United States of America.
PLoS One ; 19(6): e0304455, 2024.
Article in En | MEDLINE | ID: mdl-38935640
ABSTRACT

OBJECTIVE:

The patterning cascade model of crown morphogenesis has been studied extensively in a variety of organisms to elucidate the evolutionary history surrounding postcanine tooth form. The current research is the first to use a large modern human sample to examine whether the crown configuration of lower deciduous and permanent molars aligns with expectations derived from the model. This study has two main goals 1) to determine if metameric and antimeric pairs significantly differ in size, accessory trait expression, and relative intercusp spacing, and 2) assess whether the relative distance among early-forming cusps accounts for observed variation in accessory cusp expression.

METHODS:

Tooth size, intercusp distance, and morphological trait expression data were collected from 3D scans of mandibular dental casts representing participants of the Harvard Solomon Islands Project. Paired tests were utilized to compare tooth size, accessory trait expression, and relative intercusp distance between diphyodont metameres and permanent antimeres. Proportional odds logistic regression was implemented to investigate how the odds of greater accessory cusp expression vary as a function of the distance between early-developing cusps. RESULTS/

SIGNIFICANCE:

Comparing paired molars, significant differences were identified for tooth size and cusp 5 expression. Several relative intercusp distances emerged as important predictors of cusp 6 expression, however, results for cusp 5 and cusp 7 did not match expected patterns. These findings support previous quantitative genetic results and suggest the development of neighboring crown structures represents a zero-sum partitioning of cellular territory and resources. As such, this study contributes to a better understanding of the foundations of deciduous and permanent molar crown variation in humans.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dentition, Permanent / Tooth Crown / Molar Limits: Child / Female / Humans / Male Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2024 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dentition, Permanent / Tooth Crown / Molar Limits: Child / Female / Humans / Male Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2024 Document type: Article Affiliation country: