Oligoclonal bands.
Pract Neurol
; 24(5): 400-406, 2024 Sep 13.
Article
in En
| MEDLINE
| ID: mdl-38937092
ABSTRACT
Oligoclonal bands (OCBs) represent the presence of intrathecal immunoglobulin G (IgG) as detected by isoelectric focusing and immunofixation. Cerebrospinal fluid (CSF) analysed alongside a paired serum sample gives five different immunofixation patterns. These are type 1-the normal physiological state with no intrathecal IgG synthesis; type 2-evidence for intrathecal IgG synthesis, with CSF-restricted OCBs; type 3-evidence for intrathecal IgG synthesis, with CSF-restricted OCBs, but with additional, identical bands in the CSF and serum; type 4-absence of intrathecal IgG synthesis, but with identical OCBs in CSF and serum; and type 5-absence of intrathecal IgG synthesis, with a monoclonal band in CSF and serum. Analysis of these patterns can help to diagnose a range of neurological conditions, including multiple sclerosis. However, it is important to interpret OCB results alongside other CSF tests and their clinical context.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oligoclonal Bands
Limits:
Humans
Language:
En
Journal:
Pract Neurol
/
Pract. neurol
/
Practical neurology
Year:
2024
Document type:
Article
Country of publication: