Targeting Leishmania Promastigotes and Amastigotes Forms through Amino Acids and Peptides: A Promising Therapeutic Strategy.
ACS Infect Dis
; 10(8): 2467-2484, 2024 Aug 09.
Article
in En
| MEDLINE
| ID: mdl-38950147
ABSTRACT
Millions of people worldwide are affected by leishmaniasis, caused by the Leishmania parasite. Effective treatment is challenging due to the biological complexity of the parasite, drug toxicity, and increasing resistance to conventional drugs. To combat this disease, the development of specific strategies to target and selectively eliminate the parasite is crucial. This Review highlights the importance of amino acids in the developmental stages of Leishmania as a factor determining whether the infection progresses or is suppressed. It also explores the use of peptides as alternatives in parasite control and the development of novel targeted treatments. While these strategies show promise for more effective and targeted treatment, further studies to address the remaining challenges are imperative.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptides
/
Leishmaniasis
/
Amino Acids
/
Leishmania
/
Antiprotozoal Agents
Limits:
Animals
/
Humans
Language:
En
Journal:
ACS Infect Dis
/
ACS infect. dis
/
ACS infectious diseases
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: