[Biological threats to global malaria elimination II Deletion in the malaria rapid diagnostic test target Plasmodium falciparum histidine-rich protein 2/3 genes].
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
; 36(3): 239-242, 2024 May 23.
Article
in Zh
| MEDLINE
| ID: mdl-38952308
ABSTRACT
The global malaria epidemic is still severe. Because of simple procedures, rapid detection and accuracy results, rapid diagnostic test (RDT) has become the most important and the most widely used diagnostic tool for malaria prevention and control. However, deletions in the RDT target Plasmodium falciparum histidine-rich protein 2/3 (Pfhrp2/3) genes may cause false-negative results of RDT, which has been included as one of the four biological threats to global malaria elimination. This article reviews the applications of RDT in the global malaria diagnosis, analyzes the threats and challenges caused by Pfhrp2/3 gene deletion, proposes methods for monitoring Pfhrp2/3 gene deletion, and summarizes the causes and countermeasures of negative RDT detections, so as to provide insights into consolidation of malaria elimination achievements in China and contributions to global malaria elimination.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plasmodium falciparum
/
Protozoan Proteins
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Malaria, Falciparum
/
Gene Deletion
/
Antigens, Protozoan
Limits:
Humans
Country/Region as subject:
Asia
Language:
Zh
Journal:
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: