Heparin as a Potential Therapeutic Substance for Post-Traumatic Stress Disorder.
Bull Exp Biol Med
; 177(1): 1-9, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38954296
ABSTRACT
In sexually mature male Wistar rats with modeled post-traumatic stress disorder, personalized characteristics of neurobiological reactions in the population of predator-induced stress-resilient and stress-susceptible heparinized animals were determined. Characteristics of the systemic response of immune mechanisms, hypothalamic-pituitary-adrenal axis, behavioral manifestations, as well as basic properties of the CNS (excitation/inhibition) are presented. The study demonstrated encouraging positive results of the course administration of unfractionated heparin at a dose below the therapeutic and prophylactic doses. The inclusion of heparin drugs into the clinical practice for the treatment of post-traumatic stress disorder will not require large-scale clinical trials, because many effects of heparin as a nonspecific adaptogen are well studied. Moreover, these properties were confirmed at a higher technological level during the COVID-19 pandemic.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pituitary-Adrenal System
/
Stress Disorders, Post-Traumatic
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Heparin
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Rats, Wistar
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Hypothalamo-Hypophyseal System
Limits:
Animals
Language:
En
Journal:
Bull Exp Biol Med
Year:
2024
Document type:
Article
Affiliation country: