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Analysis of the Antimicrobial Activity of Epigallocatechin-3-Gallate (EGCG).
Muravieva, V V; Bembeeva, B O; Priputnevich, T V; Kiselev, V I.
Affiliation
  • Muravieva VV; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of Ministry of Health of Russian Federation, Moscow, Russia.
  • Bembeeva BO; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of Ministry of Health of Russian Federation, Moscow, Russia. b_bembeeva@oparina4.ru.
  • Priputnevich TV; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of Ministry of Health of Russian Federation, Moscow, Russia.
  • Kiselev VI; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of Ministry of Health of Russian Federation, Moscow, Russia.
Bull Exp Biol Med ; 177(1): 88-92, 2024 May.
Article in En | MEDLINE | ID: mdl-38960956
ABSTRACT
We studied antimicrobial activity of epigallocatechin-3-gallate (EGCG), a green tea polyphenolic catechin, and its combined use with ceftazidime (CAZ) against bacterial strains of Klebsiella pneumoniae. EGCG exhibited no activity against strains of K. pneumoniae with a different sensitivity to CAZ. However, for a "sensitive" strain, a decrease in minimum inhibitory concentration (MIC) of CAZ (from 0.064 to 0.023 mg/liter) was revealed when CAZ was co-administered with EGCG. For a "resistant" stain, MIC of CAZ remained high, but activation of EGCG at its high concentrations was observed. Indirect evidence of antimicrobial effect of EGCG co-administered with CAZ on Klebsiella was obtained.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microbial Sensitivity Tests / Catechin / Ceftazidime / Klebsiella pneumoniae / Anti-Bacterial Agents Language: En Journal: Bull Exp Biol Med Year: 2024 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microbial Sensitivity Tests / Catechin / Ceftazidime / Klebsiella pneumoniae / Anti-Bacterial Agents Language: En Journal: Bull Exp Biol Med Year: 2024 Document type: Article Affiliation country: Country of publication: