Sustained release of brimonidine from conjunctival sac insert to reduce intraocular pressure for glaucoma treatment.
Expert Opin Drug Deliv
; 21(6): 975-986, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38975698
ABSTRACT
BACKGROUND:
Glaucoma is one of the major irreversible blinding eye diseases in the world. Reducing intraocular pressure (IOP) is the primary treatment option, and taking eye drops daily is the common method. However, short drug duration and poor bioavailability of eye drops may lead to unsatisfied therapeutic effects and inadequate patient compliance.METHODS:
A brimonidine-loaded silicone rubber insert (BRI@SR@PT) was prepared by loading brimonidine into a surface-modified silicone rubber ring, followed by polydopamine/thermoplastic polyurethane coatings. The physical properties, in vitro cytocompatibility and drug release of BRI@SR@PT were investigated. The BRI@SR@PT was administrated in the conjunctival sac of rabbit eyes, and its in vivo drug release, IOP-lowering efficacy and biosafety were assessed.RESULTS:
The BRI@SR@PT presented great thermal stability and excellent elasticity. The BRI@SR@PT was able to release BRI sustainably for 28 days with little toxicity in vitro. Compared to BRI eye drops, the BRI@SR@PT effectively lowered IOP for 21 days based on the sustained BRI release with great biosafety when administrated in conjunctival sac of rabbit eyes in a noninvasive fashion.CONCLUSIONS:
The conjunctival sac insert (BRI@SR@PT), as a promising drug-delivery platform, may provide a sustained IOP-lowering treatment for patients with ocular hypertension or glaucoma, without the need for invasive procedures.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polyurethanes
/
Glaucoma
/
Delayed-Action Preparations
/
Drug Liberation
/
Brimonidine Tartrate
/
Intraocular Pressure
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Expert Opin Drug Deliv
Journal subject:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Year:
2024
Document type:
Article
Country of publication: