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Functional and clinical roles of stromal PDGF receptors in tumor biology.
Strell, Carina; Rodríguez-Tomàs, Elisabet; Östman, Arne.
Affiliation
  • Strell C; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Rodríguez-Tomàs E; Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, Bergen University, Bergen, Norway.
  • Östman A; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Article in En | MEDLINE | ID: mdl-38980580
ABSTRACT
PDGF receptors play pivotal roles in both developmental and physiological processes through the regulation of mesenchymal cells involved in paracrine instructive interactions with epithelial or endothelial cells. Tumor biology studies, alongside analyses of patient tissue samples, provide strong indications that the PDGF signaling pathways are also critical in various types of human cancer. This review summarizes experimental findings and correlative studies, which have explored the biological mechanisms and clinical relevance of PDGFRs in mesenchymal cells of the tumor microenvironment. Collectively, these studies support the overall concept that the PDGF system is a critical regulator of tumor growth, metastasis, and drug efficacy, suggesting yet unexploited targeting opportunities. The inter-patient variability in stromal PDGFR expression, as being linked to prognosis and treatment responses, not only indicates the need for stratified approaches in upcoming therapeutic investigations but also implies the potential for the development of PDGFRs as biomarkers of clinical utility, interestingly also in settings outside PDGFR-directed treatments.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Cancer Metastasis Rev Journal subject: NEOPLASIAS Year: 2024 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Cancer Metastasis Rev Journal subject: NEOPLASIAS Year: 2024 Document type: Article Affiliation country: Country of publication: