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Echocardiographic Documentation of Dilated Cardiomyopathy Development in Dogs Naturally Infected with Trypanosoma cruzi.
Avalos-Borges, Eduardo E; Acevedo-Arcique, Carlos M; Segura-Correa, Jose C; Jiménez-Coello, Matilde; Garg, Nisha J; Ortega-Pacheco, Antonio.
Affiliation
  • Avalos-Borges EE; Departamento de Salud Animal y Medicina Preventiva, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Yucatán, Km 15.5 Carretera Mérida-Xmatkuil, Apdo. Postal 4-116 Itzimná, Mérida 97000, Yucatán, Mexico.
  • Acevedo-Arcique CM; Hospital Veterinario para Perros y Gatos, Universidad Autónoma de Yucatán, Av. Itzaes No. 490 x 29, C. 18 No. 271, San José Vergel, Mérida 97000, Yucatán, Mexico.
  • Segura-Correa JC; Departamento de Salud Animal y Medicina Preventiva, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Yucatán, Km 15.5 Carretera Mérida-Xmatkuil, Apdo. Postal 4-116 Itzimná, Mérida 97000, Yucatán, Mexico.
  • Jiménez-Coello M; Laboratorio de Microbiologia, Centro de Investigaciones Regionales "Dr. Hideyo Noguchi", Universidad Autónoma de Yucatán, Av. Itzaes No. 490 x 29, Mérida 97000, Yucatán, Mexico.
  • Garg NJ; Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555-1070, USA.
  • Ortega-Pacheco A; Departamento de Salud Animal y Medicina Preventiva, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Yucatán, Km 15.5 Carretera Mérida-Xmatkuil, Apdo. Postal 4-116 Itzimná, Mérida 97000, Yucatán, Mexico.
Animals (Basel) ; 14(13)2024 Jun 26.
Article in En | MEDLINE | ID: mdl-38997996
ABSTRACT
We aimed to characterize the echocardiographic alterations in dogs from an endemic region that were naturally infected with T. cruzi. Dogs (n = 130) seropositive for antibodies against T. cruzi and/or with acute parasitemia were enrolled in the study. Indicators of changes in the structure and systolic and diastolic functions of the left ventricle (LV) and blood flow patterns were evaluated by echocardiography. The frequency and extent of alterations in these indicators were associated with the severity of the disease. Briefly, 15 (11.54%) dogs were diagnosed with dilated cardiomyopathy (DCM), and 115 (88.46%) dogs were diagnosed as being without DCM. Infected dogs with DCM exhibited structural features of LV dysfunction, e.g., a significant (p < 0.05) increase in the LV internal diameter at systole and diastole (LVID-s, LVID-d) and a decline in the LV posterior wall (LVPW-d) thickness at diastole. Despite an increase in stroke volume and cardiac output indicating contraction force, DCM resulted in a decreased ejection fraction, affecting systolic function. Dogs that were diagnosed as DCM-negative but were positive for T. cruzi by PCR exhibited a high frequency of an increase in the thickness of the interventricular septum in systole (IVS-s) and the LV posterior wall in diastole (LVPW-d), a decline in the LV inner diameter (LVID-d, LVID-s), and fractional shortening (FS). The thinning of the LVPW at systole was the most defining feature observed in chronically infected dogs. In summary, this is the first study reporting the echocardiographic changes occurring in dogs naturally infected with T. cruzi and developing DCM. Our data suggest that changes in LVID are a major indicator of risk of cardiac involvement, and the observation of changes in the IVS, LVPW, and FS have predictive value in determining the risk of DCM development in infected dogs.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Animals (Basel) Year: 2024 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Animals (Basel) Year: 2024 Document type: Article Affiliation country: Country of publication: