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The Nitrofuran-Warhead-Equipped Spirocyclic Azetidines Show Excellent Activity against Mycobacterium tuberculosis.
Komarova, Kristina; Vinogradova, Lyubov; Lukin, Alexey; Zhuravlev, Maxim; Deniskin, Dmitry; Chudinov, Mikhail; Gureev, Maxim; Dogonadze, Marine; Zabolotnykh, Natalia; Vinogradova, Tatiana; Lavrova, Anastasia; Yablonskiy, Petr.
Affiliation
  • Komarova K; Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119454 Moscow, Russia.
  • Vinogradova L; Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119454 Moscow, Russia.
  • Lukin A; Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119454 Moscow, Russia.
  • Zhuravlev M; Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119454 Moscow, Russia.
  • Deniskin D; Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119454 Moscow, Russia.
  • Chudinov M; Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119454 Moscow, Russia.
  • Gureev M; Institute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave 4, 194064 Saint Petersburg, Russia.
  • Dogonadze M; Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation, 191036 Saint Petersburg, Russia.
  • Zabolotnykh N; Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation, 191036 Saint Petersburg, Russia.
  • Vinogradova T; Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation, 191036 Saint Petersburg, Russia.
  • Lavrova A; Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation, 191036 Saint Petersburg, Russia.
  • Yablonskiy P; Sophya Kovalevskaya North-West Mathematical Research Center, Immanuel Kant Baltic Federal University, 236041 Kaliningrad, Russia.
Molecules ; 29(13)2024 Jun 27.
Article in En | MEDLINE | ID: mdl-38999023
ABSTRACT
A series of 21 new 7'H-spiro[azetidine-3,5'-furo [3,4-d]pyrimidine]s substituted at the pyrimidine ring second position were synthesized. The compounds showed high antibacterial in vitro activity against M. tuberculosis. Two compounds had lower minimum inhibitory concentrations against Mtb (H37Rv strain) compared with isoniazid. The novel spirocyclic scaffold shows excellent properties for anti-tuberculosis drug development.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spiro Compounds / Azetidines / Microbial Sensitivity Tests / Mycobacterium tuberculosis / Nitrofurans / Antitubercular Agents Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2024 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spiro Compounds / Azetidines / Microbial Sensitivity Tests / Mycobacterium tuberculosis / Nitrofurans / Antitubercular Agents Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2024 Document type: Article Affiliation country: Country of publication: