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Ferroptosis-inducing photosensitizers alleviate hypoxia tumor microenvironment for enhanced fluorescence imaging-guided photodynamic therapy.
Zhang, Linhao; He, Maomao; Xia, Xiang; Ma, Zhiyuan; Lv, Chengyuan; Wang, Ran; Liu, Wenkai; Fan, Jiangli; Peng, Xiaojun; Sun, Wen.
Affiliation
  • Zhang L; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China. sunwen@dlut.edu.cn.
  • He M; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China. sunwen@dlut.edu.cn.
  • Xia X; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China. sunwen@dlut.edu.cn.
  • Ma Z; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China. sunwen@dlut.edu.cn.
  • Lv C; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China. sunwen@dlut.edu.cn.
  • Wang R; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China. sunwen@dlut.edu.cn.
  • Liu W; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China. sunwen@dlut.edu.cn.
  • Fan J; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China. sunwen@dlut.edu.cn.
  • Peng X; Ningbo Institute of Dalian University of Technology, Ningbo 315016, China.
  • Sun W; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China. sunwen@dlut.edu.cn.
Chem Commun (Camb) ; 60(63): 8248-8251, 2024 Aug 01.
Article in En | MEDLINE | ID: mdl-39011721
ABSTRACT
This study describes H2O2-activated photosensitizer nanoparticles (ICyHD NPs), which inhibit histone deacetylase via binding Zn2+ to induce ferroptosis and upregulate the intracellular O2, thus resulting in enhanced photodynamic therapeutic effect. ICyHD NPs exert strong antitumor effects on mice and have improved the therapeutic precision via observing the increase in cellular fluorescence.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Photochemotherapy / Photosensitizing Agents / Tumor Microenvironment / Optical Imaging / Ferroptosis Limits: Animals / Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2024 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Photochemotherapy / Photosensitizing Agents / Tumor Microenvironment / Optical Imaging / Ferroptosis Limits: Animals / Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2024 Document type: Article Affiliation country: Country of publication: