Polymeric nanoparticles produced by electrohydrodynamic atomisation for the passive delivery of imatinib.
Eur J Pharm Biopharm
; 202: 114412, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-39013491
ABSTRACT
Imatinib is a chemotherapeutic agent known to cause severe side effects when administrated systemically. Encapsulating imatinib in co-polymer poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) offers a targeted drug delivery. In this work, PLGA 5050 and PLGA 7525 NPs encapsulated imatinib using the electrohydrodynamic atomisation technique. All particles generated were spherical with a smooth surface with a size distribution of 455±115 nm (PLGA 5050) and 363±147 nm (PLGA 7525). Encapsulation of imatinib was shown to be higher than 75 % and was shown to increase the zeta potential of the loaded NPs. The release of imatinib showed an initial burst in the first 12 h, followed by different sustained releases with up to 70 %. Both types of imatinib-loaded NPs' effect on cell viability and their cellular uptake were also studied on A549 cells, and the antiproliferative effect was comparable to that of cells treated with free drugs. Finally, Rhodamine-B-loaded NP-treated cells demonstrated the cellular uptake of NPs.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Particle Size
/
Drug Carriers
/
Cell Survival
/
Nanoparticles
/
Imatinib Mesylate
/
Polylactic Acid-Polyglycolic Acid Copolymer
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
Eur J Pharm Biopharm
Journal subject:
FARMACIA
/
FARMACOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: