Ca2+ signaling and metabolic stress-induced pancreatic ß-cell failure.
Front Endocrinol (Lausanne)
; 15: 1412411, 2024.
Article
in En
| MEDLINE
| ID: mdl-39015185
ABSTRACT
Early in the development of Type 2 diabetes (T2D), metabolic stress brought on by insulin resistance and nutrient overload causes ß-cell hyperstimulation. Herein we summarize recent studies that have explored the premise that an increase in the intracellular Ca2+ concentration ([Ca2+]i), brought on by persistent metabolic stimulation of ß-cells, causes ß-cell dysfunction and failure by adversely affecting ß-cell function, structure, and identity. This mini-review builds on several recent reviews that also describe how excess [Ca2+]i impairs ß-cell function.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stress, Physiological
/
Calcium Signaling
/
Diabetes Mellitus, Type 2
/
Insulin-Secreting Cells
Limits:
Animals
/
Humans
Language:
En
Journal:
Front Endocrinol (Lausanne)
Year:
2024
Document type:
Article
Affiliation country: