Primary amine-catalyzed enantioselective 1,4-Michael addition reaction of pyrazolin-5-ones to α,ß-unsaturated ketones.
Beilstein J Org Chem
; 20: 1518-1526, 2024.
Article
in En
| MEDLINE
| ID: mdl-39015621
ABSTRACT
The enantioselective 1,4-addition reaction of pyrazolin-5-ones to α,ß-unsaturated ketones catalyzed by a cinchona alkaloid-derived primary amine-Brønsted acid composite is reported. Both enantiomers of the anticipated pyrazole derivatives were obtained in good to excellent yields (up to 97%) and high enantioselectivities (up to 98.5% ee) under mild reaction conditions. In addition, this protocol was further expanded to synthesize highly enantioenriched hybrid molecules bearing biologically relevant heterocycles.
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01-internacional
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MEDLINE
Language:
En
Journal:
Beilstein J Org Chem
Year:
2024
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Article
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