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Discovery of GS-7682, a Novel 4'-Cyano-Modified C-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.
Siegel, Dustin S; Hui, Hon C; Pitts, Jared; Vermillion, Meghan S; Ishida, Kazuya; Rautiola, Davin; Keeney, Michael; Irshad, Hammad; Zhang, Lijun; Chun, Kwon; Chin, Gregory; Goyal, Bindu; Doerffler, Edward; Yang, Hai; Clarke, Michael O; Palmiotti, Chris; Vijjapurapu, Arya; Riola, Nicholas C; Stray, Kirsten; Murakami, Eisuke; Ma, Bin; Wang, Ting; Zhao, Xiaofeng; Xu, Yili; Lee, Gary; Marchand, Bruno; Seung, Minji; Nayak, Arabinda; Tomkinson, Adrian; Kadrichu, Nani; Ellis, Scott; Barauskas, Ona; Feng, Joy Y; Perry, Jason K; Perron, Michel; Bilello, John P; Kuehl, Philip J; Subramanian, Raju; Cihlar, Tomas; Mackman, Richard L.
Affiliation
  • Siegel DS; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Hui HC; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Pitts J; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Vermillion MS; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Ishida K; Lovelace Biomedical, Albuquerque, New Mexico 87108, United States.
  • Rautiola D; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Keeney M; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Irshad H; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Zhang L; Lovelace Biomedical, Albuquerque, New Mexico 87108, United States.
  • Chun K; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Chin G; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Goyal B; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Doerffler E; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Yang H; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Clarke MO; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Palmiotti C; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Vijjapurapu A; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Riola NC; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Stray K; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Murakami E; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Ma B; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Wang T; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Zhao X; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Xu Y; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Lee G; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Marchand B; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Seung M; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Nayak A; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Tomkinson A; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Kadrichu N; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Ellis S; Inspired - Pulmonary Solutions, San Carlos, California 94070, United States.
  • Barauskas O; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Feng JY; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Perry JK; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Perron M; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Bilello JP; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Kuehl PJ; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Subramanian R; Lovelace Biomedical, Albuquerque, New Mexico 87108, United States.
  • Cihlar T; Gilead Sciences, Inc., Foster City, California 94404, United States.
  • Mackman RL; Gilead Sciences, Inc., Foster City, California 94404, United States.
J Med Chem ; 67(15): 12945-12968, 2024 Aug 08.
Article in En | MEDLINE | ID: mdl-39018526
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Picornaviridae / Prodrugs / Respiratory Syncytial Virus Infections Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2024 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Picornaviridae / Prodrugs / Respiratory Syncytial Virus Infections Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2024 Document type: Article Affiliation country: Country of publication: