Dipeptidyl peptidase 4 inhibitors, sodium glucose cotransporter 2 inhibitors, and glucagon-like peptide 1 receptor agonists do not worsen diabetic macular edema.
J Diabetes Complications
; 38(8): 108808, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-39018897
ABSTRACT
AIMS:
There are limited studies on dipeptidyl-peptidase 4 inhibitor (DPP-4i), sodium glucose cotransporter 2 inhibitor (SGLT2-i), and glucagon-like peptide 1 (GLP-1) receptor agonist use and occurrence of diabetic macular edema (DME). The objective of this study was to determine the association between DPP-4i, SGLT2-i, and GLP-1 receptor agonist use and occurrence of DME.METHODS:
Proportional hazard models were used to evaluate the change in hazard of developing DME associated with DPP-4i, SGLT2-i, or GLP-1 receptor agonist use. Models accounted for age at DR diagnosis, DR severity (proliferative vs non-proliferative stage), time-weighted average of HbA1c level, sex, and self-reported race/ethnicity. A p-value ≤ 0.05 was considered statistically significant.RESULTS:
The hazard ratio of developing DME after diagnosis of DR was 1.2 (CI = 0.75 to 1.99; p = 0.43) for DPP-4i use, 0.93 (CI = 0.54 to 1.61; p = 0.81) for GLP-1 receptor agonist use, 0.82 (CI = 0.20 to 3.34; p = 0.78) for SGLT2-i use, 1.1 (CI = 0.75 to 1.59; p = 0.66) for any one medication use, 1.1 (CI = 0.62 to 2.09; p = 0.68) and for any two or more medications use.CONCLUSIONS:
We did not find an association between DPP-4i, SGLT2-i, or GLP-1 receptor agonist use and increased hazard of development of DME among patients with DR.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Macular Edema
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Diabetes Mellitus, Type 2
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Diabetic Retinopathy
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Dipeptidyl-Peptidase IV Inhibitors
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Glucagon-Like Peptide-1 Receptor
/
Sodium-Glucose Transporter 2 Inhibitors
Limits:
Aged
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
J Diabetes Complications
/
J. diabetes its complicat
/
Journal of diabetes and its complications
Journal subject:
ENDOCRINOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: