[P-glycoprotein activity in vivo in older adults: physiological, -pathophysiological and pharmacokinetic interplay at the blood-brain barrier]. / Activité de la p-glycoprotéine in vivo chez la personne âgée : intrications physiologique, physiopathologique et pharmacocinétique au niveau de la barrière hémato-encéphalique.
Geriatr Psychol Neuropsychiatr Vieil
; 22(2): 137-144, 2024 Jun 01.
Article
in Fr
| MEDLINE
| ID: mdl-39023148
ABSTRACT
p-glycoprotein (P-gp) is an efflux transporter of xenobiotic and endogenous compounds across the blood-brain barrier (BBB). P-gp plays an essential role by limiting passage of these compounds into the brain tissue. It is susceptible to drug-drug interactions when interactors drugs are co-administrated. The efficiency of P-gp may be affected by the aging process and the development of neurodegenerative diseases. Studying this protein in older adults is therefore highly relevant for all these reasons. Understanding P-gp activity in vivo is essential when considering the physiological, pathophysiological, and pharmacokinetic perspectives, as these aspects seem to be interconnected to some extent. In vivo exploration in humans is based on neuroimaging techniques, which have been improving over the last years. The advancement of exploration and diagnostic tools is opening up new prospects for understanding P-gp activity at the BBB.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood-Brain Barrier
/
ATP Binding Cassette Transporter, Subfamily B, Member 1
Limits:
Aged
/
Aged80
/
Humans
Language:
Fr
Journal:
Geriatr Psychol Neuropsychiatr Vieil
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: