Molecular mechanism underlying coencapsulating chrysophanol and hesperidin in octenylsuccinated ß-glucan aggregates for improving their corelease and bioaccessibility.
Int J Biol Macromol
; 276(Pt 2): 133902, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-39029835
ABSTRACT
Chrysophanol and hesperidin are natural nutraceuticals that exhibit synergistic bioactivities, but their hydrophobicity limits their applications, and it is unclear whether coencapsulation can improve their solubility and release behaviors. The objective of this work was to coencapsulate chrysophanol and hesperidin by octenylsuccinated ß-glucan aggregates (OSßG-Agg) and to reveal how coencapsulation improves their release and bioaccessibility. Mechanisms underlying the hypothesis of beneficial effects in coloading, corelease and bioaccessibility were revealed. The solubilization of OSßG-Agg was due to hydrogen-bonding among ß-glucan moieties of OSßG and hydroxyl groups of chrysophanol and hesperidin and hydrophobic interactions among octenyl chains of OSßG and hydrophobic moieties of chrysophanol and hesperidin. Structural analyses confirmed the hypothesis that chrysophanol molecules were nearly embedded deeper into the interior of hydrophobic domains, and most of hesperidin molecules were incorporated into the exterior of the hydrophobic domains of OSßG-Agg due to the strength of these interactions, but they interacted in OSßG-Agg with a dense and compact structure rather than existing in isolation. The combined effects delayed their release and enhanced their bioaccessibility because of dynamic equilibrium between the favorable interactions and unfavorable structural erosion and relaxation of OSßG-Agg. Overall, OSßG-Agg is effective at codelivering hydrophobic phenolics for functional foods and pharmaceuticals.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anthraquinones
/
Beta-Glucans
/
Hesperidin
Language:
En
Journal:
Int J Biol Macromol
Year:
2024
Document type:
Article
Country of publication: