Complicated Pleural Infection is Associated With Prolonged Recovery and Reduced Functional Ability.
J Bronchology Interv Pulmonol
; 31(4)2024 Oct 01.
Article
in En
| MEDLINE
| ID: mdl-39037060
ABSTRACT
BACKGROUND:
Management of complicated pleural infections (CPIs) had historically been surgical; however, following the publication of the second multicenter intrapleural sepsis trial (MIST-2), combination tissue plasminogen (tPA) and dornase (DNase) offers a less invasive and effective treatment. Our aim was to assess the quality of life (QOL) and functional ability of patients' recovery from a CPI managed with either intrapleural fibrinolytic therapy (IPFT) or surgery.METHODS:
We identified 565 patients managed for a CPI between January 1, 2013 and March 31, 2018. There were 460 patients eligible for contact, attempted through 2 phone calls and one mailer. Two questionnaires were administered the Short Form 36-Item Health Survey (SF-36) and a functional ability questionnaire.RESULTS:
Contact was made in 35% (159/460) of patients, and 57% (90/159) completed the survey. Patients had lower QOL scores compared to average US citizens; those managed with surgery had higher scores in physical functioning (surgery 80, IPFT 70, P=0.040) but lower pain scores (surgery 58, IPFT 68, P=0.045). Of 52 patients who returned to work, 48% (25) reported an impact on their work effectiveness during recovery, similarly between management strategies (IPFT 50%, 13/26 vs. surgery 46%, 12/26; P=0.781).CONCLUSION:
Patients with a CPI had a lower QOL compared with average US citizens. Surgically managed patients reported improved physical functioning but worse pain compared with patients managed with IPFT. Patients returned to work within 4 weeks of discharge, and nearly half reported their ability to work effectively was impacted by their recovery. With further research into recovery timelines, patients may be appropriately counselled for expectations.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quality of Life
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Bronchology Interv Pulmonol
Year:
2024
Document type:
Article