A novel prognostic index for extranodal natural killer/T-cell lymphoma in the era of pegaspargase/L-asparaginase.
Future Oncol
; 20(28): 2071-2081, 2024.
Article
in En
| MEDLINE
| ID: mdl-39041580
ABSTRACT
Aim:
This multicenter retrospective study aimed to develop a novel prognostic system for extranodal natural killer/T-cell lymphoma (ENKTL) patients in the era of pegaspargase/L-asparaginase.Materials &methods:
A total of 844 newly diagnosed ENKTL patients were included.Results:
Multivariable analysis confirmed that Eastern Cooperative Oncology Group performance status, lactate dehydrogenase, Chinese Southwest Oncology Group and Asia Lymphoma Study Group ENKTL (CA) system, and albumin were independent prognostic factors. By rounding up the hazard ratios from four significant variables, a maximum of 7 points were assigned. The model of Huaihai Lymphoma Working Group-Natural killer/T-cell Lymphoma prognostic index (NPI) was identified with four risk groups and the 5-year overall survival was 88.2, 66.7, 54.3 and 30.5%, respectively.Conclusion:
Huaihai Lymphoma Working Group-NPI provides a feasible stratification system for patients with ENKTL in the era of pegaspargase/L-asparaginase.
[Box see text].
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polyethylene Glycols
/
Asparaginase
/
Lymphoma, Extranodal NK-T-Cell
Limits:
Adolescent
/
Adult
/
Aged
/
Child
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Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Future Oncol
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: