Your browser doesn't support javascript.
loading
Differentiated management of ROS level in tumor and kidney to alleviate Cis-platinum induced acute kidney injury with improved efficacy.
Zhu, Shiqi; Huo, Linlin; Zeng, Jie; Chen, Rong; Sun, Yutong; Tan, Mingya; Fan, Mengke; Liu, Meiling; Zhao, Jiayi; Huang, Guoming; Wang, Yi; Xiao, Zhibo; Zhao, Zhenghuan.
Affiliation
  • Zhu S; College of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
  • Huo L; College of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
  • Zeng J; College of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
  • Chen R; College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, P. R. China.
  • Sun Y; College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, P. R. China.
  • Tan M; College of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
  • Fan M; College of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
  • Liu M; College of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
  • Zhao J; College of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
  • Huang G; College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, P. R. China.
  • Wang Y; College of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
  • Xiao Z; Department of Radiology, Daping Hospital, Army Medical University, Chongqing, 400042, China. 202530@cqmu.edu.cn.
  • Zhao Z; Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. 202530@cqmu.edu.cn.
J Nanobiotechnology ; 22(1): 436, 2024 Jul 24.
Article in En | MEDLINE | ID: mdl-39044240
ABSTRACT
Cisplatin (DDP) is a prevalent chemotherapeutic agent used in tumor therapy, yet DDP-induced acute kidney injury (AKI) severely limits its clinical application. Antioxidants as reactive oxygen species (ROS) scavengers can circumvent this adverse effect while leading to the decrease of efficacy to tumor. Herein, we report ultrasmall ruthenium nanoparticles (URNPs) as switchable ROS scavengers/generators to alleviate DDP-induced AKI and improve its therapeutic efficacy. In the physiological environment of the kidney, URNPs mimic multi-enzyme activities, such as superoxide dismutase and catalase, effectively protecting the renal cell and tissue by down-regulating the increased ROS level caused by DDP and alleviating AKI. Specifically, URNPs are oxidized by high levels of H2O2 in the tumor microenvironment (TME), resulting in the generation of oxygen vacancies and Ru3+/Ru4+ ions. This unique structure transformation endows URNPs to generate singlet oxygen (1O2) under laser irradiation and hydroxyl radicals (∙OH) through a Fenton-like reaction in tumor cell and tissue. The simultaneous generation of multifarious ROS effectively improves the efficacy of DDP in vitro and in vivo. This TME-responsive ROS scavenger/generator acts as an adjuvant therapeutic agent to minimize side effects and improve the efficacy of chemotherapy drugs, providing a new avenue to chemotherapy and facilitating clinical tumor therapy.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ruthenium / Cisplatin / Reactive Oxygen Species / Acute Kidney Injury / Kidney / Antineoplastic Agents Limits: Animals / Humans / Male Language: En Journal: J Nanobiotechnology Year: 2024 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ruthenium / Cisplatin / Reactive Oxygen Species / Acute Kidney Injury / Kidney / Antineoplastic Agents Limits: Animals / Humans / Male Language: En Journal: J Nanobiotechnology Year: 2024 Document type: Article Affiliation country: Country of publication: